Why 5-MeO-DMT for treating depression?

5-MeO-DMT provides a “reset” to the neural pathways in the brain that have formed in the development of chronic depression.  It also is well-known for often producing profound unitive states that are correlated with positive therapeutic outcomes (Davis et al., 2019; Garcia-Romeu et al., 2014; Griffiths et al., 2018). According to Dakic et al. (2017), 5-MeO-DMT serves as an anti-inflammatory agent, inhibits cell death (apoptosis), promotes dendritic arboring (neuroplasticity), which can potentially help build new neural pathways, ways of viewing self and world, and healthier habits. 5-MeO-DMT has also been shown to promote neurogenesis (new neuronal cell creation) in mice (da Cruz, Moulin, Petiz, & Leão, 2018). A single 5-MeO-DMT experience has been shown to maintain lasting therapeutic effects after, even for those who were not intending to receive such effects from it (Uthaug et al. 2019; Davis et al., 2019).

Why LSD Microdosing for treating depression?

Microdosing in general has been shown to decrease depression (Polito & Stevenson, 2019; Rootman et al., 2021; Cameron et al., 2020; Griffiths et al., 2016; Hutten et al., 2020; Kaertner et al., 2021; Lea et al., 2020), and LSD in particular has longer lasting effects/benefits than many other psychedelics, such as psilocybin.  Additionally, in a Cell Reports study, LSD was found to produce the greatest levels of dendritic arboring and neuroplasticity effects of any other psychedelic compound tested (Ly et al. 2018), thus potentially enabling the development of new, healthier habits and better ways of understanding self and world.  Additionally, microdosing has been found to lower anxiety levels (Anderson et al., 2019; Griffiths et al., 2016; Kaertner et al., 2021; Polito & Stevenson, 2019; Rosenbaum et al., 2020; Szigeti et al., 2021), and anxiety is very often comorbid with depression.

Why Microdose LSD for treating obesity?

In addition to LSD agonizing 5HT-2C receptors which produces an appetite suppressant effect, many anecdotal accounts from microdosers indicate an often-increased sense of self-care and wanting to eat healthier and in greater moderation.  

Below are excerpts from an analysis of 29 weight-loss-related posts from  https://reddit.com/r/Microdosing:

“When I dose it’s so much easier to eat like a normal person. It’s like the craving can be negotiated” with for once rather than taking over. I’ve had issues with binge eating in the past. Well every time you correct a habit you are building new pathways so the idea is that is carries over into non-microdosing life.”

“I’ve been suffering from disordered eating ever since I was a child, I’ve been going through various diets and therapy. Nothing has had such an impact on my eating patterns.  Last week I was eating a slice of cake I baked, and after a few bites all I could think was, I’m not really enjoying this anymore, it feels like I’m poisoning my body. I can safely say that I’ve never ever had this kind of thought before….”

“…LSD suppresses my appetite. Sometimes I’ll get home at night on a dose day and realize I didn’t eat anything since breakfast. It doesn’t feel like I’m starving myself, it just feels like I know the difference between eating when I’m hungry and eating when I’m bored.”

“Yes for me: healthier eating (more of portion control) and also less desire to drink alcohol. Those, along with “better” workouts and more motivation to exercise has led to weight loss.”

Delos is preparing an observational study with over 1000 participants to empirically determine the efficacy of LSD microdosing to treat obesity, depression, anxiety, and promote general wellness in life.